Electric forces to characterize future biocompatible organic electronic devices

A joint collaboration between the Institute for Bioengineering of Catalonia (IBEC), the Institute of Materials Science of Barcelona (ICMAB) and The University of Manchester has succeeded in mapping the electrical properties of organic biosensor/electrolyte interfaces at the nanoscale by measuring local electric forces. Electronic biosensors based on organic materials could make soon a reality the dream of low-cost, disposable, flexible and biocompatible electronic devices for the interaction with biological systems .

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Cells can detect the amount of space available and take decisions using their nucleus

A study published today in the journal Science shows that different cell types can use their nucleus—the cell’s stiffest and bulkiesnest organelle—to measure the level of confinement they are subjected to. These results are of particular interest for the study of cell migration, both in healthy and cancerous tissue. Marc Molina, current IBEC researcher, contributes to this article for his work done during his previous position at King’s College London

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LipoBots: robust nanomotors for biomedical applications developed with encapsulation technology

Researchers at the Institute for Bioengineering of Catalonia (IBEC) and the Catalan Institute of Nanoscience and Nanotechnology (ICN2) have developed a new type of encapsulated enzyme nanomotors.

The called LipoBots, which could be used for medical applications. LipoBots are capable to self-propulsate and to retain their enzymatic functionality in conditions similar to those of the human stomach.

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Range selectivity, a new concept that could lead to more efficient nanoparticle drug delivery 

In a new study published in the scientific journal Nature Communications, researchers describe a new concept called “range selectivity”, explaining why biomimetic nanoparticles only bind to receptors when their density is within a precise range.

This finding could pave the way for the development of highly targeted therapies against a number of diseases.

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3D printed hydrogels for cancer immunotherapy T-cell growth

The new 3D hydrogels provide high rates of cell proliferation, as they mimic lymph nodes, where T-cells reproduce in vivo. A new project, led by researchers from ICMAB and IBEC, and with the collaboration of VHIO and UIC, wants to transfer this technology to hospitals.

Cancer immunotherapy is based on using and strengthening the patient’s own immune system to recognize and fight tumor cells, without damaging healthy tissues.

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Lights, Cells, Action! IBEC develops small molecules able to control endocytosis with light

IBEC’s research group “Nanoprobes and nanoswitches” creates a system based on light to inhibit the endocytocis and control its spatio-temporal dynamics. The newly developed light-sensitive small-molecule inhibitors of endocytosis (called dynazos) are water-soluble, cell permeable, photostable, and enable fast photoswitchable inhibition of endocytosis. This technology will allow more accurate and controlled studies were endocytosis is crucial, as in cellular grow, differentiation and motility.

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A new method confirms the impact of COVID-19 confinement measures on mental health and well-being

Researchers from the SPECS lab at IBEC develop a new method to evaluate the mental health and wellbeing of people living under strict confinement measures such those during COVID-19 pandemic on April 2020. The study, conducted with people living in 17 countries, confirms that confinement measurements leads to a negative impact on the emotional wellbeing. The researchers also detected some personal situations that can entail a higher risk for the mental health and wellbeing.

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